What is Facial Mesotherapy? An Overview of its Applications, Side Effects, and Treatment Steps
Facial mesotherapy is an effective method for skin rejuvenation and regeneration, which creates controlled microchannels in the epidermis and dermis, leading to skin repair. This process helps stimulate collagen synthesis, improves scar texture, reduces open pores, and enhances skin tone and brightness. It also plays a significant role in increasing skin elasticity. In this article from Dr. Fakhriya’s journal, we will thoroughly review the treatment process, advantages, and disadvantages of this method.
What is Facial Mesotherapy?
Facial mesotherapy (collagen induction therapy) is one of the innovative and effective techniques in the field of skincare and rejuvenation, combining two methods: mesotherapy and microneedling. The effectiveness of mesotherapy is achieved by stimulating the natural skin repair process. In this method, very fine needles penetrate the superficial layers of the skin, while simultaneously, nourishing and therapeutic solutions are injected deep into the skin.
If you look at before and after photos of facial mesotherapy, you will undoubtedly notice the remarkable changes this treatment brings. The insertion of needles creates tiny, controlled wounds in the skin, prompting the body to produce more collagen and elastin. These two substances play a crucial role in maintaining skin firmness, smoothness, and youthfulness, as well as improving the texture, tone, and overall health of the skin.
What Methods are Used in Facial Mesotherapy?
Facial mesotherapy is a modern approach to skin rejuvenation that combines two techniques: mesotherapy and microneedling. In mesotherapy, vitamins, minerals, hyaluronic acid, and other nourishing compounds are injected into the middle layer of the skin. These substances directly enter the mesoderm of the skin and help enhance skin freshness, collagen production, and address certain skin issues such as dryness or discoloration. They also play a key role in skin hydration and cellular regeneration.
Things You Should Know Before Undergoing Facial Mesotherapy
Before undergoing this procedure, it is essential to follow certain guidelines and precautions. Paying attention to these tips will increase the effectiveness of the treatment and prevent potential side effects. Below are the important things to consider before undergoing facial mesotherapy:
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Stop taking blood-thinning medications such as aspirin, ibuprofen, and some supplements like vitamin E or omega-3.
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Avoid exfoliators and irritating products 3 to 5 days prior to the treatment.
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Do not undergo other skin treatments at least two weeks before mesotherapy.
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Shave the treatment area if necessary.
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Avoid sunburn and tanning beds at least two weeks before the treatment.
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Cleanse your skin thoroughly on the day of the treatment.
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Inform the doctor about any illnesses or medications you are taking.
How Does the Facial Mesotherapy Treatment Process Work?
Mesotherapy gradually and purposefully stimulates the skin to regenerate and produce collagen. The process starts by creating tiny pores on the skin’s surface, which naturally activates the body’s repair response. This process improves the skin’s texture, reduces wrinkles and spots, and also helps treat acne.
During the treatment, nutrients and mesotherapy cocktails penetrate the deeper layers of the skin. These compounds include vitamins, antioxidants, hyaluronic acid, and peptides, which play an essential role in nourishing cells and increasing skin moisture.
After the treatment, the skin enters the regeneration and repair phase, which may take a few days. During this period, the skin may appear slightly red and sensitive, but it will gradually improve, and visible results will appear. Depending on the skin type and the severity of the skin issues, the treatment may need to be repeated over several sessions with specific intervals.
Features of the Facial Mesotherapy Device
The mesotherapy device is a specialized tool in the field of skincare and beauty that is designed for a specific process and plays a key role in stimulating cellular regeneration, rejuvenation, and improving skin texture. The device works by simultaneously performing mechanical stimulation and cellular nourishment. Key components of this device include:
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Needle Cartridge: Contains several very fine needles made from stainless steel or titanium that penetrate the skin at high speed. The depth of these needles is adjustable, depending on the skin type and the treatment goal.
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Digital or Mechanical Motor: Controls the speed and intensity of the needle strokes. In advanced models, this motor is digitally adjustable.
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Injection Reservoir (in Mesogan models): Some devices, like Mesogan, have a special reservoir to hold mesotherapy cocktails, which are injected into the skin simultaneously with microneedling.
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Control Panel: In professional devices, settings related to speed, needle depth, needle type, and operation mode are adjusted via a digital display.
Steps in Facial Mesotherapy Treatment
Mesotherapy is a specialized, multi-step process for skin rejuvenation and repair, and should be performed by a dermatologist to maximize its effectiveness. Below are the steps involved in the treatment:
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Cleansing and Skin Preparation
The skin is thoroughly cleaned using gentle cleansers and disinfecting toners to remove dirt, oils, and makeup. This step plays a crucial role in preventing inflammation and infection.
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Application of Topical Numbing Cream
A topical numbing cream is applied to reduce pain and discomfort during the procedure. The cream is left on the skin for about 20 to 30 minutes, then removed to ensure no residue remains.
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Microneedling with a Specialized Device
In this step, the doctor uses the fine needles of the mesotherapy device (like Dermapen or Mesogan) on the skin. These needles create microscopic pores in the skin, stimulating the production of collagen and elastin. The depth of needle penetration is adjusted based on skin type and treatment goal.
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Injection of Mesotherapy Cocktails Simultaneously with Microneedling or Immediately After
In this stage, mesotherapy cocktails containing vitamins, hyaluronic acid, peptides, and antioxidants are injected into the deeper layers of the skin. These substances help nourish the cells, increase moisture, reduce spots, and improve skin texture.
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Post-Treatment Relaxation and Care
After the treatment, the skin may become slightly red and sensitive. Cooling masks or healing creams are used to reduce inflammation.
Types of Facial and Skin Mesotherapy
Mesotherapy can be divided into different types based on the treatment goals and skin type, with each having its own features and specific applications. Below is a table of common types of facial and skin mesotherapy:
| Types of Facial and Skin Mesotherapy | Features | Applications / Benefits |
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| Classic Mesotherapy (Superficial to Medium Depth) | Uses hyaluronic acid, vitamins, and minerals | Hydration, rejuvenation, wrinkle reduction, skin texture improvement |
| Mesotherapy with RF | Combined with PRP or collagen-boosting cocktails, with radiofrequency energy | Skin tightening, reducing sagging, scar treatment, longer-lasting effects |
| Mesotherapy with Medicinal Cocktails | Includes hyaluronic acid, B & C vitamins, arbutin (licorice extract) | Brightening, deep hydration, acne scar treatment, improving skin firmness |
| Mesotherapy for Hair and Eyebrows | Injection of nutrients into the scalp or eyebrows to strengthen follicles | Prevents hair loss, stimulates hair regrowth |
| Mesotherapy with Herbal Compounds | Uses plant extracts (aloe vera, green tea) | Hydration, reducing inflammation, improving skin color |

